Glutathione depletion and carbon ion radiation potentiate clustered DNA lesions, cell death and prevent chromosomal changes in cancer cells progeny.

Glutathione depletion and carbon ion radiation potentiate clustered DNA lesions, cell death and prevent chromosomal changes in cancer cells progeny.

Poor local control and tumor escape are of major concern in head-and-neck cancers treated by conventional radiotherapy or hadrontherapy. Reduced glutathione (GSH) is suspected of playing an important role in mechanisms leading to radioresistance, and its depletion should enable oxidative stress insu...

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Bibliographic Details
Main Authors: Maïté Hanot, Anthony Boivin, Céline Malésys, Michaël Beuve, Anthony Colliaux, Nicolas Foray, Thierry Douki, Dominique Ardail, Claire Rodriguez-Lafrasse
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3502420?pdf=render

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http://europepmc.org/articles/PMC3502420?pdf=render

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