ISO, via Upregulating MiR-137 Transcription, Inhibits GSK3β-HSP70-MMP-2 Axis, Resulting in Attenuating Urothelial Cancer Invasion

ISO, via Upregulating MiR-137 Transcription, Inhibits GSK3β-HSP70-MMP-2 Axis, Resulting in Attenuating Urothelial Cancer Invasion

Our most recent studies demonstrate that miR-137 is downregulated in human bladder cancer (BC) tissues, while treatment of human BC cells with isorhapontigenin (ISO) elevates miR-137 abundance. Since ISO showed a strong inhibition of invasive BC formation in the N-butyl-N-(4-hydroxybutyl) nitrosamin...

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Bibliographic Details
Main Authors: Xirui Guo, Haishan Huang, Honglei Jin, Jiheng Xu, Sanjiv Risal, Jingxia Li, Xin Li, Huiying Yan, Xingruo Zeng, Lei Xue, Changyan Chen, Chuanshu Huang
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253118301148

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http://www.sciencedirect.com/science/article/pii/S2162253118301148

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