Arachidonic Acid Metabolism Controls Macrophage Alternative Activation Through Regulating Oxidative Phosphorylation in PPARγ Dependent Manner

Arachidonic Acid Metabolism Controls Macrophage Alternative Activation Through Regulating Oxidative Phosphorylation in PPARγ Dependent Manner

Macrophage polarization is mainly steered by metabolic reprogramming in the tissue microenvironment, thus leading to distinct outcomes of various diseases. However, the role of lipid metabolism in the regulation of macrophage alternative activation is incompletely understood. Using human THP-1 and m...

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Bibliographic Details
Main Authors: Miao Xu, Xiaohong Wang, Yongning Li, Xue Geng, Xudong Jia, Lishi Zhang, Hui Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
macrophage alternative activation
arachidonic acid metabolism
peroxisome proliferator-activated receptor gamma (PPARgamma)
oxidative phosphorylation (OXPHOS)
prostaglandin E2 (PGE2)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.618501/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.618501/full

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