HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells.

HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells.

Endothelin 1 (ET-1) is a key regulator of vascular homeostasis. We have recently reported that the presence of Human antigen class I, HLA-B35, contributes to human dermal microvascular endothelial cell (HDMEC) dysfunction by upregulating ET-1 and proinflammatory genes. Likewise, a Toll-like receptor...

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Bibliographic Details
Main Authors: Stefania Lenna, Izabela Chrobak, G Alessandra Farina, Fernando Rodriguez-Pascual, Santiago Lamas, Robert Lafyatis, Raffaella Scorza, Maria Trojanowska
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3575387?pdf=render

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http://europepmc.org/articles/PMC3575387?pdf=render

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