Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow

Abstract Nanoparticle‐based therapeutic formulations are being increasingly explored for the treatment of various ailments. Despite numerous advances, the success of nanoparticle‐based technologies in treating brain diseases has been limited. Translational hurdles of nanoparticle therapies are attri...

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Bibliographic Details
Main Authors: Maksymilian Nowak, Tyler D. Brown, Adam Graham, Matthew E. Helgeson, Samir Mitragotri
Format: Article
Language:English
Published: Wiley 2020-05-01
Series:Bioengineering & Translational Medicine
Subjects:
BBB
Online Access:https://doi.org/10.1002/btm2.10153