Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow
Abstract Nanoparticle‐based therapeutic formulations are being increasingly explored for the treatment of various ailments. Despite numerous advances, the success of nanoparticle‐based technologies in treating brain diseases has been limited. Translational hurdles of nanoparticle therapies are attri...
Main Authors: | Maksymilian Nowak, Tyler D. Brown, Adam Graham, Matthew E. Helgeson, Samir Mitragotri |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2020-05-01
|
Series: | Bioengineering & Translational Medicine |
Subjects: | |
Online Access: | https://doi.org/10.1002/btm2.10153 |
Similar Items
-
A microfluidic model of human brain (μHuB) for assessment of blood brain barrier
by: Tyler D. Brown, et al.
Published: (2019-05-01) -
Thromboinflammation Model-On-A-Chip by Whole Blood Microfluidics on Fixed Human Endothelium
by: Alexander Dupuy, et al.
Published: (2021-01-01) -
In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device
by: Jin-Ha Choi, et al.
Published: (2019-12-01) -
Vascularized Microfluidics and the Blood–Endothelium Interface
by: Christopher A. Hesh, et al.
Published: (2019-12-01) -
Solid Lipid Nanoparticles (SLNs): An Advanced Drug Delivery System Targeting Brain through BBB
by: Mantosh Kumar Satapathy, et al.
Published: (2021-07-01)