Local and Global Rigidification Upon Antibody Affinity Maturation

During the affinity maturation process the immune system produces antibodies with higher specificity and activity through various rounds of somatic hypermutations in response to an antigen. Elucidating the affinity maturation process is fundamental in understanding immunity and in the development of...

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Bibliographic Details
Main Authors: Monica L. Fernández-Quintero, Johannes R. Loeffler, Lisa M. Bacher, Franz Waibl, Clarissa A. Seidler, Klaus R. Liedl
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00182/full