Identification and utilization of copy number information for correcting Hi-C contact map of cancer cell lines

Identification and utilization of copy number information for correcting Hi-C contact map of cancer cell lines

Abstract Background Hi-C and its variant techniques have been developed to capture the spatial organization of chromatin. Normalization of Hi-C contact map is essential for accurate modeling and interpretation of high-throughput chromatin conformation capture (3C) experiments. Hi-C correction tools...

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Bibliographic Details
Main Authors: Ahmed Ibrahim Samir Khalil, Siti Rawaidah Binte Mohammad Muzaki, Anupam Chattopadhyay, Amartya Sanyal
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Bioinformatics
Subjects:
Chromosome conformation capture (3C)
Hi-C normalization tool
Read depth
Copy number variation (CNV)
Generalized linear model (GLM)
Poisson regression
Online Access:http://link.springer.com/article/10.1186/s12859-020-03832-8

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http://link.springer.com/article/10.1186/s12859-020-03832-8

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