Design, Synthesis and Trypanocidal Evaluation of Novel 1,2,4-Triazoles-3-thiones Derived from Natural Piperine

Design, Synthesis and Trypanocidal Evaluation of Novel 1,2,4-Triazoles-3-thiones Derived from Natural Piperine

The work reported herein describes the synthesis and the assessment of the trypanocidal activity of thirteen new 1,2,4-triazole-3-thiones obtained from natural piperine, the main constituent of the dry fruits of Piper nigrum. It is part of a research program aiming to use abundant and easily availab...

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Bibliographic Details
Main Authors: Marco Edilson Freire de Lima, Lucia Mendonça-Previato, Rosane Nora Castro, Julliana de Nazareth Sá Diniz, José Osvaldo Previato, Leonardo Freire-de-Lima, Tatiany Nunes Franklim
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Molecules
Subjects:
Trypanosoma cruzi
Piper nigrum
antiparasitic drugs
bioisosterism
molecular hybridization
Online Access:http://www.mdpi.com/1420-3049/18/6/6366

Internet

http://www.mdpi.com/1420-3049/18/6/6366

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