Nuclear pore assembly proceeds by an inside-out extrusion of the nuclear envelope

Nuclear pore assembly proceeds by an inside-out extrusion of the nuclear envelope

The nuclear pore complex (NPC) mediates nucleocytoplasmic transport through the nuclear envelope. How the NPC assembles into this double membrane boundary has remained enigmatic. Here, we captured temporally staged assembly intermediates by correlating live cell imaging with high-resolution electron...

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Bibliographic Details
Main Authors: Shotaro Otsuka, Khanh Huy Bui, Martin Schorb, M Julius Hossain, Antonio Z Politi, Birgit Koch, Mikhail Eltsov, Martin Beck, Jan Ellenberg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-09-01
Series:eLife
Subjects:
correlative light-electron microscopy
electron tomography
live cell imaging
nuclear envelope
nuclear pore complex
super-resolution microscopy
Online Access:https://elifesciences.org/articles/19071

Internet

https://elifesciences.org/articles/19071

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