Plasmodium falciparum infection induces expression of a mosquito salivary protein (Agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis.

Plasmodium falciparum infection induces expression of a mosquito salivary protein (Agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis.

Invasion of mosquito salivary glands (SGs) by Plasmodium falciparum sporozoites is an essential step in the malaria life cycle. How infection modulates gene expression, and affects hematophagy remains unclear.Using Affimetrix chip microarray, we found that at least 43 genes are differentially expres...

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Bibliographic Details
Main Authors: Michael Waisberg, Alvaro Molina-Cruz, Daniella M Mizurini, Nidhi Gera, Beatriz C Sousa, Dongying Ma, Ana C Leal, Tainá Gomes, Michalis Kotsyfakis, José M C Ribeiro, Jan Lukszo, Karine Reiter, Stephen F Porcella, Carlo J Oliveira, Robson Q Monteiro, Carolina Barillas-Mury, Susan K Pierce, Ivo M B Francischetti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4161438?pdf=render

Internet

http://europepmc.org/articles/PMC4161438?pdf=render

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