1,2,4-Triazine Sulfonamides: Synthesis by Sulfenamide Intermediates, In Vitro Anticancer Screening, Structural Characterization, and Molecular Docking Study

1,2,4-Triazine Sulfonamides: Synthesis by Sulfenamide Intermediates, In Vitro Anticancer Screening, Structural Characterization, and Molecular Docking Study

In this study, we synthesized novel sulfonamides with a 1,2,4-triazine moiety according to pharmacophore requirements for biological activity. All the synthesized compounds were tested in vitro to verify whether they exhibited anticancer activity against the human breast cancer cell lines MCF-7 and...

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Bibliographic Details
Main Authors: Danuta Branowska, Zbigniew Karczmarzyk, Ewa Wolińska, Waldemar Wysocki, Maja Morawiak, Zofia Urbańczyk-Lipkowska, Anna Bielawska, Krzysztof Bielawski
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
anticancer activity
conformational analysis
molecular docking
sulfonamides
X-ray analysis
Online Access:https://www.mdpi.com/1420-3049/25/10/2324

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https://www.mdpi.com/1420-3049/25/10/2324

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