Primary treatment results of Nasopharyngeal Carcinoma (NPC) in Yogyakarta, Indonesia.
INTRODUCTION:Nasopharyngeal Carcinoma (NPC) is a major health problem in southern and eastern Asia. In Indonesia NPC is the most frequent cancer in the head and neck area. NPC is very sensitive to radiotherapy resulting in 3-year disease-free and overall survival of approximately 70% and 80%, respec...
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3651124?pdf=render |
id |
doaj-e7dae0a950fb4a2ca8677040cd94b231 |
---|---|
record_format |
Article |
spelling |
doaj-e7dae0a950fb4a2ca8677040cd94b2312020-11-25T02:33:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0185e6370610.1371/journal.pone.0063706Primary treatment results of Nasopharyngeal Carcinoma (NPC) in Yogyakarta, Indonesia.Maarten A WildemanRenske FlesCamelia HerdiniRai S IndrasariAndrew D VincentMaesadji TjokronagoroSharon StokerJohan KurniandaBaris KarakullukcuKartika W Taroeno-HariadiOlga Hamming-VriezeJaap M MiddeldorpBambang HariwiyantoSofia M HaryanaI Bing TanINTRODUCTION:Nasopharyngeal Carcinoma (NPC) is a major health problem in southern and eastern Asia. In Indonesia NPC is the most frequent cancer in the head and neck area. NPC is very sensitive to radiotherapy resulting in 3-year disease-free and overall survival of approximately 70% and 80%, respectively. Here we present routine treatment results in a prospective study on NPC in a top referral; university hospital in Indonesia. METHODS:All NPC patients presenting from September 2008 till January 2011 at the ear, nose and throat (ENT) department of the Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia, were possible candidates. Patients were included if the biopsy was a histological proven NPC without distant metastasis and were assessed during counselling sessions prior to treatment, as being able to complete the entire treatment. RESULTS:In total 78 patients were included for treatment analysis. The median time between diagnosis and start of radiotherapy is 120 days. Forty-eight (62%) patients eventually finished all fractions of radiotherapy. The median duration of the radiotherapy is 62 days for 66 Gy. Median overall survival is 21 months (95% CI 18-35) from day of diagnosis. CONCLUSION:The results presented here reveal that currently the treatment of NPC at an Indonesian hospital is not sufficient and cannot be compared to the treatment results in literature. Main reasons for these poor treatment results are (1) a long waiting time prior to the start of radiotherapy, (2) the extended overall duration of radiotherapy and (3) the advanced stage of disease at presentation.http://europepmc.org/articles/PMC3651124?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maarten A Wildeman Renske Fles Camelia Herdini Rai S Indrasari Andrew D Vincent Maesadji Tjokronagoro Sharon Stoker Johan Kurnianda Baris Karakullukcu Kartika W Taroeno-Hariadi Olga Hamming-Vrieze Jaap M Middeldorp Bambang Hariwiyanto Sofia M Haryana I Bing Tan |
spellingShingle |
Maarten A Wildeman Renske Fles Camelia Herdini Rai S Indrasari Andrew D Vincent Maesadji Tjokronagoro Sharon Stoker Johan Kurnianda Baris Karakullukcu Kartika W Taroeno-Hariadi Olga Hamming-Vrieze Jaap M Middeldorp Bambang Hariwiyanto Sofia M Haryana I Bing Tan Primary treatment results of Nasopharyngeal Carcinoma (NPC) in Yogyakarta, Indonesia. PLoS ONE |
author_facet |
Maarten A Wildeman Renske Fles Camelia Herdini Rai S Indrasari Andrew D Vincent Maesadji Tjokronagoro Sharon Stoker Johan Kurnianda Baris Karakullukcu Kartika W Taroeno-Hariadi Olga Hamming-Vrieze Jaap M Middeldorp Bambang Hariwiyanto Sofia M Haryana I Bing Tan |
author_sort |
Maarten A Wildeman |
title |
Primary treatment results of Nasopharyngeal Carcinoma (NPC) in Yogyakarta, Indonesia. |
title_short |
Primary treatment results of Nasopharyngeal Carcinoma (NPC) in Yogyakarta, Indonesia. |
title_full |
Primary treatment results of Nasopharyngeal Carcinoma (NPC) in Yogyakarta, Indonesia. |
title_fullStr |
Primary treatment results of Nasopharyngeal Carcinoma (NPC) in Yogyakarta, Indonesia. |
title_full_unstemmed |
Primary treatment results of Nasopharyngeal Carcinoma (NPC) in Yogyakarta, Indonesia. |
title_sort |
primary treatment results of nasopharyngeal carcinoma (npc) in yogyakarta, indonesia. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
INTRODUCTION:Nasopharyngeal Carcinoma (NPC) is a major health problem in southern and eastern Asia. In Indonesia NPC is the most frequent cancer in the head and neck area. NPC is very sensitive to radiotherapy resulting in 3-year disease-free and overall survival of approximately 70% and 80%, respectively. Here we present routine treatment results in a prospective study on NPC in a top referral; university hospital in Indonesia. METHODS:All NPC patients presenting from September 2008 till January 2011 at the ear, nose and throat (ENT) department of the Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia, were possible candidates. Patients were included if the biopsy was a histological proven NPC without distant metastasis and were assessed during counselling sessions prior to treatment, as being able to complete the entire treatment. RESULTS:In total 78 patients were included for treatment analysis. The median time between diagnosis and start of radiotherapy is 120 days. Forty-eight (62%) patients eventually finished all fractions of radiotherapy. The median duration of the radiotherapy is 62 days for 66 Gy. Median overall survival is 21 months (95% CI 18-35) from day of diagnosis. CONCLUSION:The results presented here reveal that currently the treatment of NPC at an Indonesian hospital is not sufficient and cannot be compared to the treatment results in literature. Main reasons for these poor treatment results are (1) a long waiting time prior to the start of radiotherapy, (2) the extended overall duration of radiotherapy and (3) the advanced stage of disease at presentation. |
url |
http://europepmc.org/articles/PMC3651124?pdf=render |
work_keys_str_mv |
AT maartenawildeman primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia AT renskefles primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia AT cameliaherdini primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia AT raisindrasari primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia AT andrewdvincent primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia AT maesadjitjokronagoro primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia AT sharonstoker primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia AT johankurnianda primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia AT bariskarakullukcu primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia AT kartikawtaroenohariadi primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia AT olgahammingvrieze primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia AT jaapmmiddeldorp primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia AT bambanghariwiyanto primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia AT sofiamharyana primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia AT ibingtan primarytreatmentresultsofnasopharyngealcarcinomanpcinyogyakartaindonesia |
_version_ |
1724812198265487360 |