Alpha‐synuclein dynamics in induced pluripotent stem cell‐derived dopaminergic neurons from a Parkinson’s disease patient (PARK4) with SNCA triplication

Alpha‐synuclein dynamics in induced pluripotent stem cell‐derived dopaminergic neurons from a Parkinson’s disease patient (PARK4) with SNCA triplication

Parkinson's disease (PD) is a neurodegenerative disorder caused by the selective loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Lewy bodies (LBs), another histological hallmark of PD, are observed in patients with familial or sporadic PD. The therapeutic potentia...

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Bibliographic Details
Main Authors: Hayato Fukusumi, Kazuyuki Togo, Miho Sumida, Masayuki Nakamori, Satoshi Obika, Kousuke Baba, Tomoko Shofuda, Daisuke Ito, Hideyuki Okano, Hideki Mochizuki, Yonehiro Kanemura
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:FEBS Open Bio
Subjects:
dopaminergic neuron
human‐induced pluripotent stem cell
PARK4
Parkinson's disease
SNCA triplication
α‐synuclein
Online Access:https://doi.org/10.1002/2211-5463.13060

Internet

https://doi.org/10.1002/2211-5463.13060

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