Associations between the development of PTSD symptoms and longitudinal changes in the DNA methylome of deployed military servicemen: A comparison with polygenic risk scores

Associations between the development of PTSD symptoms and longitudinal changes in the DNA methylome of deployed military servicemen: A comparison with polygenic risk scores

Objective: Military servicemen deployed to war zones are at increased risk of developing posttraumatic stress disorder (PTSD) and successful adaptation to stress is important. Epigenetic alterations in response to trauma have been identified as mechanism of adaptation and may therefore predict deplo...

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Bibliographic Details
Main Authors: Sija J. van der Wal, Adam X. Maihofer, Christiaan H. Vinkers, Alicia K. Smith, Caroline M. Nievergelt, Dawayland O. Cobb, Monica Uddin, Dewleen G. Baker, Nicolaas P.A. Zuithoff, Bart P.F. Rutten, Eric Vermetten, Elbert Geuze, Marco P. Boks
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Comprehensive Psychoneuroendocrinology
Subjects:
DNA methylation
EP300
Epigenetics
miRNA1281
Posttraumatic stress disorder
Prediction
Online Access:http://www.sciencedirect.com/science/article/pii/S2666497620300187

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http://www.sciencedirect.com/science/article/pii/S2666497620300187

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