Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy.

Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy.

Interleukin-21 (IL-21), a member of the common cytokine receptor γ chain (γc) family, is secreted by CD4+ T cells and natural killer T cells and induces effector function through interactions with the IL-21 receptor (IL-21R)/γc complex expressed on both immune and non-immune cells. Numerous studies...

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Bibliographic Details
Main Authors: Reena Varkey, Qun Du, Jodi L Karnell, Xiaodong Xiao, Kerry A Casey, Rob Woods, Kim Rosenthal, Susan Wilson, William F Dall'Acqua, Herren Wu, Ronald Herbst, Rachel Ettinger, Melissa Damschroder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0211236

Internet

https://doi.org/10.1371/journal.pone.0211236

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