Ursolic acid derivative UA232 evokes apoptosis of lung cancer cells induced by endoplasmic reticulum stress

Ursolic acid derivative UA232 evokes apoptosis of lung cancer cells induced by endoplasmic reticulum stress

Context Ursolic acid (UA), a natural product, shows a broad spectrum of anticancer effects. However, the poor bioavailability and efficacy of UA limit its clinical application. Objective We developed novel analogues of UA with enhanced antitumor activities by the extensive chemical modification of U...

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Bibliographic Details
Main Authors: Wenfeng Gou, Na Luo, Huiqiang Wei, Hongying Wu, Xiaojun Yu, Yuqing Duan, Changfen Bi, Hongxin Ning, Wenbin Hou, Yiliang Li
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Pharmaceutical Biology
Subjects:
non-small cell lung cancer
endoplasmic reticulum stress
Online Access:http://dx.doi.org/10.1080/13880209.2020.1794013

Internet

http://dx.doi.org/10.1080/13880209.2020.1794013

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