An Aγ-globin G->A gene polymorphism associated with β039 thalassemia globin gene and high fetal hemoglobin production

An Aγ-globin G->A gene polymorphism associated with β039 thalassemia globin gene and high fetal hemoglobin production

Abstract Background Increase of the expression of γ-globin gene and high production of fetal hemoglobin (HbF) in β-thalassemia patients is widely accepted as associated with a milder or even asymptomatic disease. The search for HbF-associated polymorphisms (such as the XmnI, BCL11A and MYB polymorph...

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Bibliographic Details
Main Authors: Giulia Breveglieri, Nicoletta Bianchi, Lucia Carmela Cosenza, Maria Rita Gamberini, Francesco Chiavilli, Cristina Zuccato, Giulia Montagner, Monica Borgatti, Ilaria Lampronti, Alessia Finotti, Roberto Gambari
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Medical Genetics
Subjects:
β-thalassemia
Fetal hemoglobin
LYAR
Aγ-globin gene polymorphism
Online Access:http://link.springer.com/article/10.1186/s12881-017-0450-3

Internet

http://link.springer.com/article/10.1186/s12881-017-0450-3

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