The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53

The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53

Amplification of MYCN is a poor prognostic feature in neuroblastoma (NBL) indicating aggressive disease. We and others have shown BET bromodomain inhibitors (BETi) target MYCN indirectly by downregulating its transcription. Here we sought to identify agents that synergize with BETi and to identify b...

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Bibliographic Details
Main Authors: Joanna S. Yi, Oscar Sias-Garcia, Nicole Nasholm, Xiaoyu Hu, Amanda Balboni Iniguez, Matthew D. Hall, Mindy Davis, Rajarshi Guha, Myrthala Moreno-Smith, Eveline Barbieri, Kevin Duong, Jessica Koach, Jun Qi, James E. Bradner, Kimberly Stegmaier, William A. Weiss, W. Clay Gustafson
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Neuroblastoma
MYCN
TP53
Synergy
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000282

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http://www.sciencedirect.com/science/article/pii/S1476558621000282

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