A central role for glial CCR5 in directing the neuropathological interactions of HIV-1 Tat and opiates

A central role for glial CCR5 in directing the neuropathological interactions of HIV-1 Tat and opiates

Abstract Background The collective cognitive and motor deficits known as HIV-associated neurocognitive disorders (HAND) remain high even among HIV+ individuals whose antiretroviral therapy is optimized. HAND is worsened in the context of opiate abuse. The mechanism of exacerbation remains unclear bu...

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Bibliographic Details
Main Authors: Sarah Kim, Yun Kyung Hahn, Elizabeth M Podhaizer, Virginia D McLane, Shiping Zou, Kurt F Hauser, Pamela E Knapp
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Neuroinflammation
Subjects:
Human immunodeficiency virus
Morphine
C-C chemokine receptor 5
Maraviroc
Brain-derived neurotrophic factor
NeuroHIV
Online Access:http://link.springer.com/article/10.1186/s12974-018-1320-4

Internet

http://link.springer.com/article/10.1186/s12974-018-1320-4

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