Effects of concomitant use of prasugrel with edoxaban on bleeding time, pharmacodynamics, and pharmacokinetics of edoxaban in healthy elderly Japanese male subjects: a clinical pharmacology study

Effects of concomitant use of prasugrel with edoxaban on bleeding time, pharmacodynamics, and pharmacokinetics of edoxaban in healthy elderly Japanese male subjects: a clinical pharmacology study

Abstract Background Dual therapy with a direct oral anticoagulant (DOAC) plus a P2Y12 receptor inhibitor is recommended in patients with nonvalvular atrial fibrillation who undergo percutaneous coronary intervention. Thus, we evaluated the effects of DOAC edoxaban plus P2Y12 receptor inhibitor prasu...

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Bibliographic Details
Main Authors: Ippei Ikushima, Takaaki Akasaka, Yoshiyuki Morishima, Atsushi Takita, Tomoko Motohashi, Tetsuya Kimura
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Thrombosis Journal
Subjects:
Edoxaban
Prasugrel
Healthy male subjects
Elderly Japanese
Bleeding time
Pharmacodynamics
Online Access:http://link.springer.com/article/10.1186/s12959-020-00223-0

Internet

http://link.springer.com/article/10.1186/s12959-020-00223-0

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