Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development.

Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development.

The developing testis provides an environment that nurtures germ cell development, ultimately ensuring spermatogenesis and fertility. Impacts on this environment are considered to underlie aberrant germ cell development and formation of germ cell tumour precursors. The signaling events involved in t...

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Bibliographic Details
Main Authors: Denise C Miles, Stephanie I Wakeling, Jessica M Stringer, Jocelyn A van den Bergen, Dagmar Wilhelm, Andrew H Sinclair, Patrick S Western
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3546992?pdf=render

Internet

http://europepmc.org/articles/PMC3546992?pdf=render

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