BRCA1 and BRCA2 Mutations Other Than the Founder Alleles Among Ashkenazi Jewish in the Population of Argentina

BRCA1 and BRCA2 Mutations Other Than the Founder Alleles Among Ashkenazi Jewish in the Population of Argentina

In Ashkenazi Jewish (AJ) high risk families 3 mutations [2 in BRCA1 (c. 68_69del and c.5266dup) and 1 in BRCA2 (c.5946del)] account for the majority of high risk breast and ovarian cancer cases in that ethnic group. Few studies with limited number of genotyped individuals have expanded the spectrum...

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Bibliographic Details
Main Authors: Angela R. Solano, Natalia C. Liria, Fernanda S. Jalil, Daniela M. Faggionato, Pablo G. Mele, Alejandra Mampel, Florencia C. Cardoso, Ernesto J. Podesta
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Oncology
Subjects:
non-founder Ashkenazi BRCA1/2 mutations
Ashkenazi Jewish
hereditary breast and ovary cancer
BRCA1
BRCA2
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00323/full

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https://www.frontiersin.org/article/10.3389/fonc.2018.00323/full

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