Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury

Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury

Abstract Background The pathological process of traumatic spinal cord injury (SCI) involves excessive activation of microglia leading to the overproduction of proinflammatory cytokines and causing neuronal injury. Sphingosine kinase 1 (Sphk1), a key enzyme responsible for phosphorylating sphingosine...

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Bibliographic Details
Main Authors: Chenjian Wang, Tianzhen Xu, Brittany Bolduc Lachance, Xiqiang Zhong, Guangjie Shen, Tao Xu, Chengxuan Tang, Xiaofeng Jia
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Neuroinflammation
Subjects:
Sphk1
Spinal cord injury
M1 microglia
NF-κB p65 activation
S1P/S1PR3/p38 MAPK pathway
Online Access:https://doi.org/10.1186/s12974-021-02092-4

Internet

https://doi.org/10.1186/s12974-021-02092-4

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