Differential Requirement of Cd8 Enhancers E8I and E8VI in Cytotoxic Lineage T Cells and in Intestinal Intraepithelial Lymphocytes

Differential Requirement of Cd8 Enhancers E8I and E8VI in Cytotoxic Lineage T Cells and in Intestinal Intraepithelial Lymphocytes

CD8 expression in T lymphocytes is tightly regulated by the activity of at least six Cd8 enhancers (E8I-E8VI), however their complex developmental stage-, subset-, and lineage-specific interplays are incompletely understood. Here we analyzed ATAC-seq data on the Immunological Genome Project database...

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Bibliographic Details
Main Authors: Alexandra Franziska Gülich, Teresa Preglej, Patricia Hamminger, Marlis Alteneder, Caroline Tizian, Maria Jonah Orola, Sawako Muroi, Ichiro Taniuchi, Wilfried Ellmeier, Shinya Sakaguchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
T cell development
gene regulation
CD8
enhancer
transgenic/knockout mice
cytotoxic T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00409/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00409/full

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