Delivery of antisense peptide nucleic acids to cells by conjugation with small arginine-rich cell-penetrating peptide (R/W)9.

Delivery of antisense peptide nucleic acids to cells by conjugation with small arginine-rich cell-penetrating peptide (R/W)9.

Peptide nucleic acids (PNAs) are very attractive antisense and antigene agents, but these molecules are not passively taken into cells. Here, using a functional cell assay and fluorescent-based methods, we investigated cell uptake and antisense activity of a tridecamer PNA that targets the HIV-1 pol...

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Bibliographic Details
Main Authors: Céline Cordier, Fatima Boutimah, Mathilde Bourdeloux, Florian Dupuy, Elisabeth Met, Patrizia Alberti, François Loll, Gérard Chassaing, Fabienne Burlina, Tula Ester Saison-Behmoaras
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4134252?pdf=render

Internet

http://europepmc.org/articles/PMC4134252?pdf=render

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