p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.

p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.

The PMK-1 p38 mitogen-activated protein kinase pathway and the DAF-2-DAF-16 insulin signaling pathway control Caenorhabditis elegans intestinal innate immunity. pmk-1 loss-of-function mutants have enhanced sensitivity to pathogens, while daf-2 loss-of-function mutants have enhanced resistance to pat...

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Bibliographic Details
Main Authors: Emily R Troemel, Stephanie W Chu, Valerie Reinke, Siu Sylvia Lee, Frederick M Ausubel, Dennis H Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1635533?pdf=render

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http://europepmc.org/articles/PMC1635533?pdf=render

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