The MTR A2756G polymorphism is associated with an increase of plasma homocysteine concentration in Brazilian individuals with Down syndrome

The MTR A2756G polymorphism is associated with an increase of plasma homocysteine concentration in Brazilian individuals with Down syndrome

Individuals with Down syndrome (DS) present decreased homocysteine (Hcy) concentration, reflecting a functional folate deficiency secondary to overexpression of the cystathionine ß-synthase gene. Since plasma Hcy may be influenced by genetic polymorphisms, we evaluated the influence of C677T and A12...

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Bibliographic Details
Main Authors: J.M Biselli, E.M Goloni-Bertollo, R Haddad, M.N Eberlin, E.C Pavarino-Bertelli
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2008-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Down syndrome
Trisomy 21
Polymorphism
Homocysteine
Mass spectrometry (LC-MS/MS)
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000100006

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000100006

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