T cell mediated immunity induced by the live-attenuated Shigella flexneri 2a vaccine candidate CVD 1208S in humans

T cell mediated immunity induced by the live-attenuated Shigella flexneri 2a vaccine candidate CVD 1208S in humans

Abstract Background Shigellosis persists as a public health problem worldwide causing ~ 165,000 deaths every year, of which ~ 55,000 are in children less than 5 years of age. No vaccine against shigellosis is currently licensed. The live-attenuated Shigella flexneri 2a vaccine candidate CVD 1208S (S...

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Bibliographic Details
Main Authors: Franklin R. Toapanta, Paula J. Bernal, Karen L. Kotloff, Myron M. Levine, Marcelo B. Sztein
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Translational Medicine
Subjects:
Shigella flexneri 2a
Oral vaccine
CVD 1208S
T cell mediated immunity
IpaB
Nanoparticles
Online Access:http://link.springer.com/article/10.1186/s12967-018-1439-1

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http://link.springer.com/article/10.1186/s12967-018-1439-1

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