Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers

Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers

Checkpoint inhibitors target the inhibitory receptors expressed by tumor-infiltrating T cells in order to reinvigorate an anti-tumor immune response. Therefore, understanding T cell composition and phenotype in human tumors is crucial. We analyzed by flow cytometry tumor-infiltrating lymphocytes (TI...

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Bibliographic Details
Main Authors: Laurence C. Menard, Paul Fischer, Bijal Kakrecha, Peter S. Linsley, Erik Wambre, Maochang C. Liu, Blake J. Rust, Deborah Lee, Becky Penhallow, Nataly Manjarrez Orduno, Steven G. Nadler
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
renal cell carcinoma (RCC)
CD4+CD8+ T cells
T cell dysfunction
TIM-3
PD-1
clonal expansion
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02728/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02728/full

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