Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers
Checkpoint inhibitors target the inhibitory receptors expressed by tumor-infiltrating T cells in order to reinvigorate an anti-tumor immune response. Therefore, understanding T cell composition and phenotype in human tumors is crucial. We analyzed by flow cytometry tumor-infiltrating lymphocytes (TI...
Main Authors: | Laurence C. Menard, Paul Fischer, Bijal Kakrecha, Peter S. Linsley, Erik Wambre, Maochang C. Liu, Blake J. Rust, Deborah Lee, Becky Penhallow, Nataly Manjarrez Orduno, Steven G. Nadler |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-11-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02728/full |
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