Peptide-Targeted Polyplexes for Aerosol-Mediated Gene Delivery to CD49f-Overexpressing Tumor Lesions in Lung

Peptide-Targeted Polyplexes for Aerosol-Mediated Gene Delivery to CD49f-Overexpressing Tumor Lesions in Lung

Peptide ligands can enhance delivery of nucleic acid-loaded nanoparticles to tumors by promoting their cell binding and internalization. Lung tumor lesions accessible from the alveolar side can be transfected, in principle, using gene vectors delivered as an aerosol. The cell surface marker CD49f (I...

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Bibliographic Details
Main Authors: Alexander Taschauer, Wolfram Polzer, Fatih Alioglu, Magdalena Billerhart, Simon Decker, Theresa Kittelmann, Emanuela Geppl, Salma Elmenofi, Martin Zehl, Ernst Urban, Haider Sami, Manfred Ogris
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253119303051

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http://www.sciencedirect.com/science/article/pii/S2162253119303051

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