Overexpressing TGF-β1 in mesenchymal stem cells attenuates organ dysfunction during CLP-induced septic mice by reducing macrophage-driven inflammation

Overexpressing TGF-β1 in mesenchymal stem cells attenuates organ dysfunction during CLP-induced septic mice by reducing macrophage-driven inflammation

Abstract Background Sepsis remains a leading cause of death in critically ill patients. It is well known that mesenchymal stem cells (MSCs) are a promising therapy partly due to their paracrine-mediated immunoregulatory function. Previous study demonstrated that transforming growth factor-beta1 (TGF...

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Bibliographic Details
Main Authors: Feng Liu, Jianfeng Xie, Xiwen Zhang, Zongsheng Wu, Shi Zhang, Ming Xue, Jianxiao Chen, Yi Yang, Haibo Qiu
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Sepsis
Transforming growth factor-β1
Macrophage activation
Online Access:http://link.springer.com/article/10.1186/s13287-020-01894-2

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http://link.springer.com/article/10.1186/s13287-020-01894-2

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