Systemic administration of substance P recovers beta amyloid-induced cognitive deficits in rat: involvement of Kv potassium channels.

Systemic administration of substance P recovers beta amyloid-induced cognitive deficits in rat: involvement of Kv potassium channels.

Reduced levels of Substance P (SP), an endogenous neuropeptide endowed with neuroprotective and anti-apoptotic properties, have been found in brain and spinal fluid of Alzheimer's disease (AD) patients. Potassium (K(+)) channel dysfunction is implicated in AD development and the amyloid-β (Aβ)-...

Full description

Bibliographic Details
Main Authors: Patrizia Campolongo, Patrizia Ratano, Maria Teresa Ciotti, Fulvio Florenzano, Stefania Lucia Nori, Roberta Marolda, Maura Palmery, Anna Maria Rinaldi, Cristina Zona, Roberta Possenti, Pietro Calissano, Cinzia Severini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3827079?pdf=render

Internet

http://europepmc.org/articles/PMC3827079?pdf=render

Similar Items