TGFβ induces stemness through non-canonical AKT-FOXO3a axis in oral squamous cell carcinoma

TGFβ induces stemness through non-canonical AKT-FOXO3a axis in oral squamous cell carcinoma

Background: FOXO3a has been widely regarded as a tumor suppressor. It also plays a paradoxical role in regulating the cancer stem cells (CSCs), responsible for tumor-initiation, chemo-resistance, and recurrence in various solid tumors, including oral squamous cell carcinoma (OSCC). This study aims t...

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Bibliographic Details
Main Authors: Kan Li, Le Yang, Jingyuan Li, Chenyu Guan, Sien Zhang, Xiaomei Lao, Daiqiao Ouyang, Guangsen Zheng, Siyong Gao, Dikan Wang, Yujie Liang, Guiqing Liao
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419306310

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http://www.sciencedirect.com/science/article/pii/S2352396419306310

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