Tumor Long Interspersed Nucleotide Element-1 (LINE-1) Hypomethylation in Relation to Age of Colorectal Cancer Diagnosis and Prognosis

Tumor Long Interspersed Nucleotide Element-1 (LINE-1) Hypomethylation in Relation to Age of Colorectal Cancer Diagnosis and Prognosis

Evidence indicates the pathogenic role of epigenetic alterations in early-onset colorectal cancers diagnosed before age 50. However, features of colorectal cancers diagnosed at age 50–54 (hereafter referred to as “intermediate-onset”) remain less known. We hypothesized that tumor long interspersed n...

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Bibliographic Details
Main Authors: Naohiko Akimoto, Melissa Zhao, Tomotaka Ugai, Rong Zhong, Mai Chan Lau, Kenji Fujiyoshi, Junko Kishikawa, Koichiro Haruki, Kota Arima, Tyler S. Twombly, Xuehong Zhang, Edward L. Giovannucci, Kana Wu, Mingyang Song, Andrew T. Chan, Yin Cao, Jeffrey A. Meyerhardt, Kimmie Ng, Marios Giannakis, Juha P. Väyrynen, Jonathan A. Nowak, Shuji Ogino
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
carcinogenesis
colorectal neoplasms
epigenomics
genomic instability
long interspersed nuclear element
molecular pathology
Online Access:https://www.mdpi.com/2072-6694/13/9/2016

Internet

https://www.mdpi.com/2072-6694/13/9/2016

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