REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.

In mammals, many aspects of behavior and physiology, and in particular cellular metabolism, are coordinated by the circadian timing system. Molecular clocks are thought to rely on negative feedback loops in clock gene expression that engender oscillations in the accumulation of transcriptional regul...

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Bibliographic Details
Main Authors: Gwendal Le Martelot, Thierry Claudel, David Gatfield, Olivier Schaad, Benoît Kornmann, Giuseppe Lo Sasso, Antonio Moschetta, Ueli Schibler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19721697/?tool=EBI