Lipothioureas as Lipids for Gene Transfection: A Review

Lipothioureas as Lipids for Gene Transfection: A Review

Non-viral gene therapy requires innovative strategies to achieve higher transfection efficacy. A few years ago, our group proposed bioinspired lipids whoseinteraction with DNA was not based on ionic interactions, but on hydrogen bonds. We thusdeveloped lipids bearing a thiourea head which allowed an...

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Bibliographic Details
Main Authors: Jean Herscovici, Nathalie Mignet, Michel Bessodes, Jeanne Leblond, Isabelle Tranchant, Daniel Scherman, Marie Breton
Format: Article
Language:English
Published: MDPI AG 2011-10-01
Series:Pharmaceuticals
Subjects:
lipothiourea
thiourea lipids
DNA
lipoplexes
transfection
gene therapy
Online Access:http://www.mdpi.com/1424-8247/4/10/1381/

Internet

http://www.mdpi.com/1424-8247/4/10/1381/

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