Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity

Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity

Abstract Purpose Our study aimed to elucidate the intracellular processes associated with quinolinic acid (QA)-induced brain injury by acquiring semiquantitative fluorescent images of reactive oxygen species (ROS) generation and positron emission tomography (PET) images of mitochondrial complex I (M...

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Bibliographic Details
Main Authors: Rie Hosoi, Yuka Fujii, Ohba Hiroyuki, Miho Shukuri, Shingo Nishiyama, Masakatsu Kanazawa, Kenichiro Todoroki, Yasushi Arano, Toshihiro Sakai, Hideo Tsukada, Osamu Inoue
Format: Article
Language:English
Published: SpringerOpen 2021-10-01
Series:EJNMMI Research
Subjects:
Reactive oxygen species
Mitochondrial complex I
Dihydroethidium
18F-BCPP-EF
Quinolinic acid
Microglia
Online Access:https://doi.org/10.1186/s13550-021-00841-3

Internet

https://doi.org/10.1186/s13550-021-00841-3

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