A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies
Abstract Microglial dysfunction has been proposed as one of the many cellular mechanisms that can contribute to the development of Alzheimer’s disease (AD). Here, using a transcriptional network map of the human frontal cortex, we identify five modules of co-expressed genes related to microglia and...
Main Authors: | , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-01-01
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Series: | Translational Psychiatry |
Online Access: | https://doi.org/10.1038/s41398-020-01175-9 |