A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies

A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies

Abstract Microglial dysfunction has been proposed as one of the many cellular mechanisms that can contribute to the development of Alzheimer’s disease (AD). Here, using a transcriptional network map of the human frontal cortex, we identify five modules of co-expressed genes related to microglia and...

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Bibliographic Details
Main Authors: Ellis Patrick, Marta Olah, Mariko Taga, Hans-Ulrich Klein, Jishu Xu, Charles C. White, Daniel Felsky, Sonal Agrawal, Chris Gaiteri, Lori B. Chibnik, Sara Mostafavi, Julie A. Schneider, David A. Bennett, Elizabeth M. Bradshaw, Philip L. De Jager
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-020-01175-9

Internet

https://doi.org/10.1038/s41398-020-01175-9

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