Resistance mutation R292K is induced in influenza A(H6N2) virus by exposure of infected mallards to low levels of oseltamivir.

Resistance mutation R292K is induced in influenza A(H6N2) virus by exposure of infected mallards to low levels of oseltamivir.

Resistance to neuraminidase inhibitors (NAIs) is problematic as these drugs constitute the major treatment option for severe influenza. Extensive use of the NAI oseltamivir (Tamiflu®) results in up to 865 ng/L of its active metabolite oseltamivir carboxylate (OC) in river water. There one of the nat...

Full description

Bibliographic Details
Main Authors: Anna Gillman, Shaman Muradrasoli, Hanna Söderström, Johan Nordh, Caroline Bröjer, Richard H Lindberg, Neus Latorre-Margalef, Jonas Waldenström, Björn Olsen, Josef D Järhult
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3741332?pdf=render

Internet

http://europepmc.org/articles/PMC3741332?pdf=render

Similar Items