Homoharringtonine inhibits fibroblasts proliferation, extracellular matrix production and reduces surgery-induced knee arthrofibrosis via PI3K/AKT/mTOR pathway-mediated apoptosis

Homoharringtonine inhibits fibroblasts proliferation, extracellular matrix production and reduces surgery-induced knee arthrofibrosis via PI3K/AKT/mTOR pathway-mediated apoptosis

Abstract Background The prevention of surgery-induced intraarticular fibrosis remains a challenge following orthopedic surgery. Homoharringtonine (HHT) has been reported to have positive effects in preventing various kinds of fibrosis. However, little is known regarding its effect as well as the pot...

Full description

Bibliographic Details
Main Authors: Yu Sun, Jihang Dai, Rui Jiao, Qing Jiang, Jingcheng Wang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Homoharringtonine
Fibroblasts proliferation
Fibroblast apoptosis
Intraarticular fibrosis
PI3K/AKT/mTOR signaling pathway
Online Access:https://doi.org/10.1186/s13018-020-02150-2

Internet

https://doi.org/10.1186/s13018-020-02150-2

Similar Items