Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice

The microenvironment of solid tumours is extremely acidic and this condition arises since the precancerous stage. This acidic milieu could therefore provide a useful target for both prophylactic and therapeutic approaches. In TRAMP transgenic mice, an in vivo model of prostate adenocarcinoma (AC), o...

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Bibliographic Details
Main Authors: Simonetta Astigiano, Andrea Puglisi, Luca Mastracci, Stefano Fais, Ottavia Barbieri
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Online Access:http://dx.doi.org/10.1080/14756366.2016.1252760