Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus

Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus

As a prominent inflammatory effector of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2) mediates brain inflammation and injury in many chronic central nervous system (CNS) conditions including seizures and epilepsy, largely through its receptor subtype EP2. However, EP2 receptor activation might a...

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Bibliographic Details
Main Authors: Jianxiong Jiang, Myung-soon Yang, Yi Quan, Paoula Gueorguieva, Thota Ganesh, Raymond Dingledine
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Neurobiology of Disease
Subjects:
Epilepsy
Seizure
Status epilepticus
Neuroinflammation
Cyclooxygenase
Prostaglandin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000042

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http://www.sciencedirect.com/science/article/pii/S0969996115000042

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