Increase of CD4+CD25highFoxP3+ cells impairs in vitro human microbicidal activity against Mycobacterium tuberculosis during latent and acute pulmonary tuberculosis.

Increase of CD4+CD25highFoxP3+ cells impairs in vitro human microbicidal activity against Mycobacterium tuberculosis during latent and acute pulmonary tuberculosis.

<h4>Background</h4>Regulatory T cells (Tregs) play a critical role during Mycobacterium tuberculosis (Mtb) infection, modulating host responses while neutralizing excessive inflammation. However, their impact on regulating host protective immunity is not completely understood. Here, we d...

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Bibliographic Details
Main Authors: Lorenzzo Lyrio Stringari, Luciana Polaco Covre, Flávia Dias Coelho da Silva, Vivian Leite de Oliveira, Maria Carolina Campana, David Jamil Hadad, Moisés Palaci, Padmini Salgame, Reynaldo Dietze, Daniel Cláudio de Oliveira Gomes, Rodrigo Ribeiro-Rodrigues
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0009605

Internet

https://doi.org/10.1371/journal.pntd.0009605

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