A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human

A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human

Due to the limited proliferation capacity of adult mammalian cardiomyocytes, the human heart has negligible regenerative capacity after injury. Here the authors show that a Hedgehog-Gli1-Mycn signaling cascade regulates cardiomyocyte proliferation and cardiac regeneration from amphibians to mammals.

Bibliographic Details
Main Authors: Bhairab N. Singh, Naoko Koyano-Nakagawa, Wuming Gong, Ivan P. Moskowitz, Cyprian V. Weaver, Elizabeth Braunlin, Satyabrata Das, Jop H. van Berlo, Mary G. Garry, Daniel J. Garry
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06617-z

Internet

https://doi.org/10.1038/s41467-018-06617-z

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