Insight to the molecular mechanisms of the osmolyte effects on Mycobacterium tuberculosis pyrazinamidase stability using experimental studies, molecular dynamics simulations, and free energy calculation

Insight to the molecular mechanisms of the osmolyte effects on Mycobacterium tuberculosis pyrazinamidase stability using experimental studies, molecular dynamics simulations, and free energy calculation

Background: In this study, we have experimentally investigated the effects of different osmolytes including sucrose, sorbitol, urea, and guanidinium chloride (GdmCl) on the stability and structure of the Mycobacterium tuberculosis pyrazinamidase (PZase). PZase converts pyrazinamide to its active for...

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Bibliographic Details
Main Authors: Mohadese Khajehzadeh, Saeedeh Khaleghnejad, Faramarz Mehrnejad, Mohammad Pazhang, Farahnoosh Doustdar
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:International Journal of Mycobacteriology
Subjects:
Molecular dynamics simulation
Mycobacterium tuberculosis
osmolytes
pyrazinamidase
Online Access:http://www.ijmyco.org/article.asp?issn=2212-5531;year=2018;volume=7;issue=3;spage=268;epage=274;aulast=Khajehzadeh

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http://www.ijmyco.org/article.asp?issn=2212-5531;year=2018;volume=7;issue=3;spage=268;epage=274;aulast=Khajehzadeh

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