RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer’s disease

RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer’s disease

Abstract Background Exosomes are lipid-bilayer enclosed nano-sized vesicles that transfer functional cellular proteins, mRNA and miRNAs. Mesenchymal stem cells (MSCs) derived exosomes have been demonstrated to prevent memory deficits in the animal model of Alzheimer’s disease (AD). However, the intr...

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Bibliographic Details
Main Authors: Guo-hong Cui, Hai-dong Guo, Han Li, Yu Zhai, Zhang-bin Gong, Jing Wu, Jian-sheng Liu, You-rong Dong, Shuang-xing Hou, Jian-ren Liu
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Immunity & Ageing
Subjects:
Alzheimer’s disease
Exosomes
Targeting
Mesenchymal stem cells
Inflammatory cytokine
Online Access:http://link.springer.com/article/10.1186/s12979-019-0150-2

Internet

http://link.springer.com/article/10.1186/s12979-019-0150-2

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