Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat Stress.

Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat Stress.

Thermal ablative therapies are important treatment options in the multidisciplinary care of patients with hepatocellular carcinoma (HCC), but lesions larger than 2-3 cm are plagued with high local recurrence rates and overall survival of these patients remains poor. Currently no adjuvant therapies e...

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Bibliographic Details
Main Authors: Scott M Thompson, Matthew R Callstrom, Danielle E Jondal, Kim A Butters, Bruce E Knudsen, Jill L Anderson, Karen R Lien, Shari L Sutor, Ju-Seog Lee, Snorri S Thorgeirsson, Joseph P Grande, Lewis R Roberts, David A Woodrum
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5017586?pdf=render

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http://europepmc.org/articles/PMC5017586?pdf=render

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