Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein–Taybi syndrome etiology

Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein–Taybi syndrome etiology

Rubinstein–Taybi syndrome (RSTS) is a complex autosomal-dominant disease characterized by mental and growth retardation and skeletal abnormalities. A majority of the individuals diagnosed with RSTS carry heterozygous mutation in the gene CREBBP, but a small percentage of cases are caused by mutation...

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Bibliographic Details
Main Authors: Jose Viosca, Jose P. Lopez-Atalaya, Roman Olivares, Richard Eckner, Angel Barco
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Neurobiology of Disease
Subjects:
Mental retardation
Rubinstein–Taybi syndrome
Histone acetyltransferase
Learning and memory
Mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002782

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http://www.sciencedirect.com/science/article/pii/S0969996109002782

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